1991. 2 M.D. College of Medicine, CNU, Korea
1996. 2 Ph.D. College of Medicine, CNU, Korea
경력
1997 - 2003 College of Medicine, CNU [Full-time instructor]
1997-1999 College of Medicine, CNU [Assistant Professor]
2002 Tokyo Medical and Dental University [Visiting Scientist]
2003 - 2004 Imperial College London, U. K. [Research Associate]
2004 - 2008 Dept. of Microbiology, College of Medicine, CNU [Associate Professor,]
2007 - 2016 Medical Research Center (ISNRC), CNU [Director]
2008 - present Dept. of Microbiology, College of Medicine, CNU [Professor]
관심연구분야
- Host-pathogen interaction in tuberculosis and other infections
- Signaling mechanisms for controlling inflammatory responses
- Development of therapeutic modalities to target infection and
연구실 소개
미생물학교실
Host-pathogen interaction during microbial infection is importantly involved in determination of disease outcome. The interaction of microbes with innate receptors triggers intracellular signaling cascades that culminate in a proinflammatory response and antimicrobial responses. However, it should be tightly regulated to prevent excessive and exacerbated inflammatory responses, often harmful to host. Our laboratory focused on the studies to decipher molecular networks dependent on Toll-like receptor (TLR) signaling in macrophages infected with Mycobacterium tuberculosis or specific mycobacterial antigens. Understanding intracellular signaling network during mycobacterial infection will provide new therapeutic strategies against human tuberculosis and atypical mycobacterial diseases.
